Mice

Mice to genetically manipulate muscle

Pax7CreERT2: Mice we developed to manipulate fetal, neonatal, and adult (satellite cells) muscle stem cells. In the adult, at least 95% of satellite cells are genetically labeled with YFP in Pax7CreERT2/+;R26RYFP mice. These mice are described in Murphy et al. 2011 and available at Jax.

Mice to genetically manipulate muscle connective tissue fibroblasts

Tcf4GFPCre: Mice we developed (in collaboration with Melinda Angus-Hil and Mario Capecchi) to manipulate muscle connective tissue fibroblasts. At P0, Tcf4GFPCre+Neo mice label 58% of the fibroblasts, and no myogeneic cells, while Tcf4GFPCre-Neo mice label 100% of the fibroblasts, but label some myogenic cells (probably myofibers). Both mice are described in Mathew et al. 2011 and available by contacting Gabrielle.

Tcf4CreERT2: Mice we developed (in collaboration with Melinda Angus-Hill and Mario Capecchi) to manipulate muscle connective tissue fibroblasts, primarily in the adult. At 6 weeks, Tcf4CreERT2 mice label 45% of the fibroblasts. The mice are described in Murphy et al. 2011 and available by contacting Gabrielle.